Environmental biotechnology is concerned with the application of biotechnological techniques to foster and preserve the environment, which means to keep a balance between the physical and biological matters on this planet. The basis for such a balance can be found in the form of the natural cycles of matter. It is therefore of utter importance to find techniques and scientific applications to be able to foster, improve and increase the activities of these natural cycles in order to cope with an increasing human and animal population. Encyclopedia of Environmental Biotechnology discusses a Green Approach to Pollution Control that focuses on the role of environmental biotechnology in developing sustainable solutions for pollution control. By harnessing microbial and enzymatic processes, bioremediation offers an eco-friendly alternative to conventional physical and chemical remediation methods. Chapters demonstrate the use of microorganisms to detoxify heavy metals, degrade hydrocarbons, and restore contaminated ecosystems, making bioremediation a cornerstone of the green technology movement. Precision Medicine examines how molecular profiling, genetic analysis, and targeted therapies are enabling personalized treatment strategies. Instead of a “one-size-fits-all” approach, precision medicine tailor’s interventions based on the genetic makeup of both the patient and the tumor. Advances in biomarker discovery, genomic sequencing, and computational oncology are discussed alongside emerging immunotherapies and combination treatments, offering new hope for improved patient outcomes. Genomics and Transcriptomics: Tools and Applications explore how genomics and transcriptomics are used to study genetic structures, functions, and gene expression patterns in various organisms. Applications range from identifying disease associated genes to improving crop varieties and understanding microbial communities. The discussion extends to next-generation sequencing technologies, bioinformatics pipelines, and integrated omics approaches that provide a more comprehensive understanding of biological systems. Plant–Microbe Interactions and Soil Health examines the symbiotic and associative relationships between plants and beneficial microbes, such as mycorrhizal fungi and nitrogen-fixing bacteria. It outlines how these interactions influence nutrient cycling, plant growth, and resilience to stress, while also addressing the implications for sustainable agriculture.